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Src-2

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Src-2

Nuclear receptor coactivator 2
1GWQ
Available structures
PDB Ortholog search: RCSB
Identifiers
NCOA2 Gene
RNA expression pattern

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Function

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.[1][2]

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).[3]

Interactions

Nuclear receptor coactivator 2 has been shown to interact with:

References

Further reading

External links

  • Medical Subject Headings (MeSH)
  • C90
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