World Library  
Flag as Inappropriate
Email this Article

Schistosoma

Article Id: WHEBN0000377559
Reproduction Date:

Title: Schistosoma  
Author: World Heritage Encyclopedia
Language: English
Subject: Flatworm, Schistosoma mansoni, Digenea, Schistosoma japonicum, Helminths
Collection: Digenea, Parasites of Humans
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Schistosoma

A disease, (after malaria), with hundreds of millions infected worldwide.[1][2]

Adult flatworms parasitize blood capillaries of either the mesenteries or plexus of the bladder, depending on the infecting species. They are unique among trematodes and any other flatworms in that they are dioecious with distinct sexual dimorphism between male and female. Thousands of eggs are released and reach either the bladder or the intestine (according to the infecting species), and these are then excreted in urine or feces to fresh water. Larvae must then pass through an intermediate snail host, before the next larval stage of the parasite emerges that can infect a new mammalian host by directly penetrating the skin.

Contents

  • Evolution 1
  • Taxonomy 2
    • New species 2.1
    • Cladogram 2.2
  • Comparison of eggs 3
  • Schistosomiasis 4
    • Species infecting humans 4.1
    • Species infecting other animals 4.2
  • Morphology 5
  • Reproduction 6
  • Genome 7
  • History 8
  • References 9
  • External links 10

Evolution

Electron micrograph of an adult male Schistosoma parasite worm. The bar (bottom left) represents a length of 500 μm.

The origins of this [3] The original hosts for the South East Asian species were probably rodents.

Based on the phylogenetics of the host snails it seems likely that the genus evolved in Gondwana between and .[4]

The sister group to Schistosoma is a genus of elephant-infecting schistosomes — Bivitellobilharzia. The cattle, sheep, goat and cashmere goat parasite Orientobilharzia turkestanicum appears to be related to the African schistosomes.[5][6] This latter species has since been transferred to the genus Schistosoma.[7]

Within the haematobium group S. bovis and S. curassoni appear to be closely related as do S. leiperi and S. mattheei.

S. mansoni appears to have evolved in East Africa 0.43–0.30 million years ago.

S. incognitum and S. nasale are more closely related to the African species rather than the japonicum group.

S. sinensium appears to have radiated during the Pliocene.

S. mekongi appears to have invaded South East Asia in the mid-Pleistocene.

Estimated speciation dates for the japonicum group: ~3.8 million years ago for S. japonicum/South East Asian schistosoma and ~2.5 million years ago for S. malayensis/S. mekongi.

Schistosoma turkestanicum is found infecting red deer in Hungary. These strains appear to have diverged from those found in China and Iran.[8] The date of divergence appears to be 270,000 years before present.

Taxonomy

The genus Schistosoma as currently defined is paraphyletic, so revisions are likely. Over twenty species are recognised within this genus.

The genus has been divided into four groups — indicum, japonicum, haematobium and mansoni. The affinities of the remaining species are still being clarified.

Thirteen species are found in Africa. Twelve of these are divided into two groups — those with a lateral spine on the egg (mansoni group) and those with a terminal spine (haematobium group).

The four mansoni group species are: S. edwardiense, S. hippotami, S. mansoni and S. rodhaini.

The nine haematobium group species are: S. bovis, S. curassoni, S. intercalatum, S. guineensis, S. haematobium, S. kisumuensis, S. leiperi, S. margrebowiei and S. matthei.

S. leiperi and S. matthei appear to be related.[9] S. margrebowiei is basal in this group.[10] S. guineensis is the sister species to the S. bovis and S. curassoni grouping. S. intercalatum may actually be a species complex of at least two species.[11][12]

S. spindale is widely distributed in Asia, but is also found in Africa.

The other species occur in Asia and India.

The indicum group has three species: S. indicum, S. nasale and S. spindale. This group appears to have evolved during the Pleistocene. All use pulmonate snails as hosts.

S. indicum is found in India and Thailand.

This group appears to be the sister clade to the African species.[13]

The japonicum group has three species: S. japonicum, S. malayensis and S. mekongi.

S. sinensium is a sister clade to the S. japonicum group and is found in China.

S. ovuncatum forms a clade with S. sinensium and is found in northern Thailand. The definitive host is the black rat (Rattus rattus) and the intermediate host is the snail Tricula bollingi. This species is known to use snails of the family Pomatiopsidae as hosts.

S. incognitum appears to be basal in this genus. It may be more closely related to the African/Indian species than to the Southeast Asian group. This species uses pulmonate snails as hosts.

New species

Four additional species have been transferred to this genus.[7] These were previously classified as species in the genus Orientobilharzia. Orientobilharzia differs from Schistosoma morphologically only on the basis of the number of testes. A review of the morphological and molecular data has shown that the differences between these genera are too small to justify their separation. The four species that have been transferred to this genus are

  • Schistosoma bomfordi
  • Schistosoma datta
  • Schistosoma harinasutai
  • Schistosoma turkestanicum

Examination of the mitochondria suggests that Schistosoma incognitum may be a species complex.[14]

Cladogram

A cladogram based on 18S ribosomal RNA, 28S ribosomal RNA, and partial cytochrome c oxidase subunit I (COI) genes shows phylogenic relations of species in the genus Schistosoma:[15]













Schistosoma curassoni


Schistosoma intercalatum



Schistosoma bovis




Schistosoma leiperi


Schistosoma mattheei




Schistosoma haematobium



Schistosoma margrebowiei





Schistosoma spindale


Schistosoma indicum



Schistosoma nasale





Schistosoma mansoni


Schistosoma rodhaini




Schistosoma incognitum



Schistosoma turkestanicum




Schistosoma edwardiense


Schistosoma sp. from Ceratophallus natalensis







Schistosoma mekongi


Schistosoma malayensis



Schistosoma japonicum




Schistosoma sinensium


Schistosoma ovuncatum




Comparison of eggs

Schistosomiasis

The parasitic flatworms of Schistosoma cause a group of chronic infections called schistosomiasis known also as bilharziasis.[16] An anti-schistosome drug is a schistosomicide.

Species infecting humans

Parasitism of humans by Schistosoma appears to have evolved at least three occasions in both Asia and Africa.

  • S. haematobium, commonly referred to as the bladder fluke, originally found in Africa, the Near East, and the Mediterranean basin, was introduced into India during World War II. Freshwater snails of the Bulinus genus are an important intermediate host for this parasite. Among final hosts humans are most important. Other final hosts are rarely baboons and monkeys.[17]
  • S. intercalatum. The usual final hosts are humans. Other animals can be infected experimentally.[17]
  • S. japonicum, whose common name is simply blood fluke, is widespread in East Asia and the southwestern Pacific region. In Taiwan this species only affects animals, not humans. Freshwater snails of the Oncomelania genus are an important intermediate host for S. japonicum. Final hosts are humans and other mammals including cats, dogs, goats, horses, pigs, rats and water buffalo.[17]
  • S. malayensis This species appears to be a rare infection in humans and is considered to be a zoonosis. The natural vertebrate host is von Muller's rat (Rattus muelleri). The snail host(s) are Robertsiella species (R. gismanni, R. kaporensis and R. silvicola (see Attwood et al. 2005 Journal of Molluscan Studies Volume 71, Issue 4 pp. 379–391).
  • S. mekongi is related to S. japonicum and affects both the superior and inferior mesenteric veins. S. mekongi differs in that it has smaller eggs, a different intermediate host (Neotricula aperta) and longer prepatent period in the mammalian host. Final hosts are humans and dogs.[17] The snail Tricula aperta can also be experimentally infected with this species.
Human Schistosomes
Scientific Name First Intermediate Host Endemic Area
Schistosoma guineensis Bulinus forskalii West Africa
Schistosoma intercalatum Bulinus spp Africa
Schistosoma haematobium Bulinus spp. Africa, Middle East
Schistosoma japonicum Oncomelania spp. China, East Asia, Philippines
Schistosoma malayensis Not known Southeast Asia
Schistosoma mansoni Biomphalaria spp. Africa, South America, Caribbean, Middle East
Schistosoma mekongi Neotricula aperta Southeast Asia

Species infecting other animals

Schistosoma indicum, Schistosoma nasale, Schistosoma spindale,Schistosoma leiperi are all parasites of ruminants.

Schistosoma edwardiense and Schistosoma hippopotami are parasites of the hippo.

Schistosoma ovuncatum and Schistosoma sinensium are parasites of rodents.

Morphology

Adult schistosomes share all the fundamental features of the digenea. They have a basic bilateral symmetry, oral and ventral suckers, a body covering of a syncytial tegument, a blind-ending digestive system consisting of mouth, esophagus and bifurcated caeca; the area between the tegument and alimentary canal filled with a loose network of mesoderm cells, and an excretory or osmoregulatory system based on flame cells. Adult worms tend to be 10–20 mm (0.4–0.8 in) long and use globins from their hosts' hemoglobin for their own circulatory system.

Reproduction

Unlike other trematodes, the schistosomes are dioecious, i.e., the sexes are separate. The two sexes display a strong degree of sexual dimorphism, and the male is considerably larger than the female. The male surrounds the female and encloses her within his gynacophoric canal for the entire adult lives of the worms, where they reproduce sexually.

Genome

The genomes of Schistosoma haematobium, S. japonicum and S. mansoni have been reported.[18][19][20][21]

History

The eggs of these parasites were first seen by Theodor Maximilian Bilharz, a German pathologist working in Egypt in 1851 who found the eggs of Schistosoma haematobium during the course of a post mortem. He wrote two letters to his former teacher von Siebold in May and August 1851 describing his findings. Von Siebold wrote a paper (published in 1852) summarizing Bilharz's findings. Bilharz wrote a paper in 1856 describing the worms more fully and he named them Distoma haematobium. Their unusual morphology meant that they could not be comfortably included in Distoma. So in 1856 Meckel von Helmsback created the genus Bilharzia for them. In 1858 Weinland proposed the name Schistosoma (Greek: "split body") after the male worms' morphology. Despite Bilharzia having precedence, the genus name Schistosoma was officially adopted by the International Commission on Zoological Nomenclature. The term Bilharzia to describe infection with these parasites is still in use in medical circles.

Bilharz also described Schistosoma mansoni, but this species was redescribed by Louis Westenra Sambon in 1907 at the London School of Tropical Medicine who named it after his teacher Patrick Manson.

In 1898, all the then known species were placed in a subfamily by Stiles and Hassel. This was then elevated to family status by Looss in 1899. Poche in 1907 corrected a grammatical error in the family name. The life cycle was determined by the Brazilian parasitologist Pirajá da Silva (1873-1961) in 1908.

In 2009, the genomes of Schistosoma mansoni and Schistosoma japonicum were decoded [18][19] opening the way for new targeted treatments. In particular, the study discovered that the genome of S. mansoni contained 11,809 genes, including many that produce enzymes for breaking down proteins, enabling the parasite to bore through tissue. Also, S. mansoni does not have an enzyme to make certain fats, so it must rely on its host to produce these.[22]

References

  1. ^
  2. ^
  3. ^
  4. ^ Beer SA, Voronin MV, Zazornova OP, Khrisanfova GG, Semenova SK (2010) Phylogenetic relationships among schistosomatidae. Med Parazitol (Mosk) 2010 (2):53-59
  5. ^
  6. ^
  7. ^ a b Aldhoun JA, Littlewood DT (2012) Orientobilharzia Dutt & Srivastava, 1955 (Trematoda: Schistosomatidae), a junior synonym of Schistosoma Weinland, 1858. Syst Parasitol 82(2):81-8. doi: 10.1007/s11230-012-9349-8
  8. ^ Lawton SP, Majoros G (2013) A foreign invader or a reclusive native? DNA bar coding reveals a distinct European lineage of the zoonotic parasite Schistosoma turkestanicum (syn. Orientobilharzia turkestanicum). Infect Genet Evol 14:186-93. doi: 10.1016/j.meegid.2012.11.013
  9. ^ Kaukas A, Dias Neto E, Simpson AJ, Southgate VR, Rollinson D (1994) A phylogenetic analysis of Schistosoma haematobium group species based on randomly amplified polymorphic DNA. Int J Parasitol 24(2):285-290
  10. ^ Webster BL, Southgate VR, Littlewood DT (2006) A revision of the interrelationships of Schistosoma including the recently described Schistosoma guineensis. Int J Parasitol 36(8):947-955
  11. ^ Kane RA, Southgate VR, Rollinson D, Littlewood DT, Lockyer AE, Pagès JR, Tchuem Tchuentè LA, Jourdane J (2003) A phylogeny based on three mitochondrial genes supports the division of Schistosoma intercalatum into two separate species. Parasitology 127(Pt 2):131-137
  12. ^ Pagès JR, Durand P, Southgate VR, Tchuem Tchuenté LA, Jourdane J (2001) Molecular arguments for splitting of Schistosoma intercalatum, into two distinct species. Parasitol Res 87(1):57-62
  13. ^ Agatsuma T, Iwagami M, Liu CX, Rajapakse RP, Mondal MM, Kitikoon V, Ambu S, Agatsuma Y, Blair D, Higuchi T (2002) Affinities between Asian non-human Schistosoma species, the S. indicum group, and the African human schistosomes. J Helminthol 76(1):7-19
  14. ^ Webster BL, Littlewood DT (2012) Mitochondrial gene order change in Schistosoma (Platyhelminthes: Digenea: Schistosomatidae). Int J Parasitol 42(3):313-321
  15. ^
  16. ^ Britannica Concise Encyclopedia 2007
  17. ^ a b c d e
  18. ^ a b
  19. ^ a b
  20. ^
  21. ^
  22. ^

External links

  • British Department for International Development Control of Schistosomiasis
  • The World Health Organisation page on Schistosomiasis
  • University of Cambridge Schistosome Laboratory
  • Schistostoma parasites overview, biology, life cycle image at MetaPathogen
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.