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Tead3

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Title: Tead3  
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Tead3

TEA domain family member 3
PDB rendering based on 2hzd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.[1][2][3]

Contents

  • Function 1
  • References 2
  • Further reading 3
  • External links 4

Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[4] It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.[5] Translation of this protein is initiated at a non-AUG (AUA) start codon.[3]

References

  1. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9.  
  2. ^ Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry 272 (20): 12928–37.  
  3. ^ a b "Entrez Gene: TEAD3 TEA domain family member 3". 
  4. ^ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–12.  
  5. ^ Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns 7 (8): 827–36.  

Further reading

  • Jiang SW, Wu K, Eberhardt NL (Jun 1999). "Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer". Molecular Endocrinology 13 (6): 879–89.  
  • Vaudin P, Delanoue R, Davidson I, Silber J, Zider A (Nov 1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation". Development 126 (21): 4807–16.  
  • Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML (May 2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes & Development 15 (10): 1229–41.  
  • Maeda T, Mazzulli JR, Farrance IK, Stewart AF (Jul 2002). "Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes". The Journal of Biological Chemistry 277 (27): 24346–52.  
  • Peng L, Huang Y, Jin F, Jiang SW, Payne AH (Aug 2004). "Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1". Molecular Endocrinology 18 (8): 2049–60.  

External links


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