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Title: Tfiib  
Author: World Heritage Encyclopedia
Language: English
Subject: Promoter (genetics), Transcription factor, TATA box, Robert G. Roeder, General transcription factor, TATA-binding protein, Transcription factor II A
Publisher: World Heritage Encyclopedia


General transcription factor IIB
PDB rendering based on 1c9b.
Available structures
PDB Ortholog search: RCSB
GTF2B Gene
RNA expression pattern

Transcription factor IIB (TFIIB) is one of several

Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between transcription factor IID, which initially recognizes the promoter sequence, and RNA polymerase II.[4] It is involved in the selection of the transcription start site; mutations in TFIIB cause a shift in the transcription start site.[5]


Transcription factor IIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID,[6][7] and the RPB1 subunit of RNA polymerase II.[7]

Transcription Factor IIB makes sequence-specific protein-DNA interactions with the B recognition element (BRE), a promoter element flanking the TATA element.[8][9] The role of TFIIB in the vast number of human promoters lacking TATA and BRE elements remains unclear.

Recent study shows that TFIIB links transcription inhibition with the p53-dependent DNA damage response. [10]

See also


Further reading

External links

  • Medical Subject Headings (MeSH)

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