World Library  
Flag as Inappropriate
Email this Article

Tfiib

Article Id: WHEBN0012589624
Reproduction Date:

Title: Tfiib  
Author: World Heritage Encyclopedia
Language: English
Subject: Promoter (genetics), Transcription factor, TATA box, Robert G. Roeder, General transcription factor, TATA-binding protein, Transcription factor II A
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Tfiib

General transcription factor IIB
PDB rendering based on 1c9b.
Available structures
PDB Ortholog search: RCSB
Identifiers
GTF2B Gene
RNA expression pattern

Transcription factor IIB (TFIIB) is one of several

Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between transcription factor IID, which initially recognizes the promoter sequence, and RNA polymerase II.[4] It is involved in the selection of the transcription start site; mutations in TFIIB cause a shift in the transcription start site.[5]

Interactions

Transcription factor IIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID,[6][7] and the RPB1 subunit of RNA polymerase II.[7]

Transcription Factor IIB makes sequence-specific protein-DNA interactions with the B recognition element (BRE), a promoter element flanking the TATA element.[8][9] The role of TFIIB in the vast number of human promoters lacking TATA and BRE elements remains unclear.

Recent study shows that TFIIB links transcription inhibition with the p53-dependent DNA damage response. [10]

See also

References

Further reading

External links

  • Medical Subject Headings (MeSH)


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.