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Title: Trim28  
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Subject: Glucocorticoid receptor, Krüppel associated box, Transcription coregulator, Cumulus oophorus
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Tripartite motif containing 28
Available structures
PDB Ortholog search: RCSB
TRIM28 Gene
RNA expression pattern

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM24 gene.[1][2]


The protein encoded by this gene mediates transcriptional control by interaction with the Krüppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.[3]


TRIM28 has been shown to interact with CBX5,[4][5][6][7] ZNF10,[8][9] CEBPB,[10][11] SETDB1[12] and Glucocorticoid receptor.[11]

See also


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

  • Medical Subject Headings (MeSH)
  • C153

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