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Transcription factor II E

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Title: Transcription factor II E  
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Subject: GTF2E2, RNA polymerase II holoenzyme, NeuroD, EMX homeogene, Nur (biology)
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Transcription factor II E

general transcription factor IIE, polypeptide 1, alpha 56kDa
Symbol GTF2E1
Alt. symbols TF2E1
Entrez 2960
HUGO 4650
OMIM 189962
RefSeq NM_005513
UniProt P29083
Other data
Locus Chr. 3 q21-q24
general transcription factor IIE, polypeptide 2, beta 34kDa
Symbol GTF2E2
Alt. symbols TF2E2
Entrez 2961
HUGO 4651
OMIM 189964
RefSeq NM_002095
UniProt P29084
Other data
Locus Chr. 8 p12

Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1]

Transcription Factor II E is encoded by the GTF2E1 and GTF2E2 genes.[2][3][4][5] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.[6]

See also


  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. p636–637.  
  2. ^ Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M (1992). "Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences". Nucleic Acids Res. 20 (21): 5838.  
  3. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4.  
  4. ^ Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG (1991). "Conserved sequence motifs in the small subunit of human general transcription factor TFIIE". Nature 354 (6352): 401–4.  
  5. ^ Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG (December 1991). "Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE". Nature 354 (6352): 398–401.  
  6. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137.  

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