World Library  
Flag as Inappropriate
Email this Article

Vaccine Safety Datalink

The Vaccine Safety Datalink Project (VSD) was established in 1990 by the United States Centers for Disease Control and Prevention (CDC) to study the adverse effects of vaccines.

Four large Kaiser Permanente, were initially recruited to provide the CDC with medical data on vaccination histories, health outcomes, and subject characteristics. The VSD database contains data compiled from surveillance on more than seven million Americans, including about 500,000 children from birth through age six years (2% of the U.S. population in this age group).[1]

The VSD data-sharing program is now being administered by the National Center for Health Statistics Research Data Center. The data sharing guidelines have been revised to include comments from interested groups as well as recommendations from the Institute of Medicine (IOM).

The Vaccine Adverse Event Reporting System (VAERS), the VSD, and the Clinical Immunization Safety Assessment (CISA) Network are tools by which the CDC and FDA measure vaccine safety[2] to fulfill their duty as regulatory agencies charged with protecting the public. Data from the VSD Project have been utilized to address a number of vaccine safety concerns; examples include a study clarifying the risk of anaphylaxis after vaccine administration[3] and several studies examining the rejected hypothesis of a link between thimerosal-containing vaccines and autism.[4][5][6]

Participating healthcare organizations

The following organizations are members of the project:[7]

  • Group Health Cooperative of Puget Sound, Seattle, Washington
  • Harvard Pilgrim Health Care, Boston, Massachusetts
  • HealthPartners Research Foundation, Minneapolis, Minnesota
  • Kaiser Permanente Northwest, Portland, Oregon
  • Kaiser Permanente Medical Care Program of Northern California, Oakland, California
  • Kaiser Permanente Colorado, Denver, Colorado
  • Kaiser Permanente of Georgia, Atlanta, Georgia
  • Marshfield Clinic Research Foundation, Marshfield, Wisconsin
  • Southern California Kaiser Permanente Health Care Program, Los Angeles, California


  1. ^ Chen RT; Glasser JW; Rhodes PH; et al. (1997). "Vaccine Safety Datalink project: a new tool for improving vaccine safety monitoring in the United States. The Vaccine Safety Datalink Team". Pediatrics 99 (6): 765–73.  
  2. ^ Centers for Disease Control and Prevention, Vaccine Safety Monitoring at CDC, retrieved 2015-03-11. 
  3. ^ Bohlke K, Davis RL, Marcy SM, et al. (2003). "Risk of anaphylaxis after vaccination of children and adolescents". Pediatrics 112 (4): 815–20.  
  4. ^ Geier DA, Geier MR (Spring 2006). "Early Downward Trends in Neurodevelopmental Disorders Following Removal of Thimerosal-Containing Vaccines" (PDF). Journal of American Physicians and Surgeons 11 (1). 
  5. ^ Verstraeten T, Davis RL, DeStefano F, et al. (2003). "Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databases". Pediatrics 112 (5): 1039–48.  
  6. ^ Thompson WW, Price C, Goodson B, et al. (2007). "Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years". N. Engl. J. Med. 357 (13): 1281–92.  
  7. ^

External links

  • - 'Independent Oversight of Vaccine Safety Data Program Needed To Ensure Greater Transparency and Enhance Public Trust', National Academies (February 17, 2005)
  • (pdf) - 'The Vaccine Safety Datalink: immunization research in health maintenance organizations in the USA', R.T. Chen, F. DeStefano, R.L. Davis, L.A. Jackson, R.S. Thompson, J.P. Mullooly, S.B. Black, H.R. Shinefield, C.M. Vadheim, J.I. Ward, S.M. Marcy & the Vaccine Safety Datalink Team, World Health Organization
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.