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Title: Xrn2  
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Subject: MicroRNA, Attenuator (genetics)
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5'-3' exoribonuclease 2

5'-3' Exoribonuclease 2 (XRN2) also known as DHM1-like protein is an exoribonuclease enzyme that in humans is encoded by the XRN2 gene.[1]

The human gene encoding XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 genes. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1.


Human XRN2 is involved in the torpedo model of transcrption termination.[2]

The C. elegans homologue, XRN-2, is involved in the degradation of certain mature miRNAs and their dislodging from miRISC miRNAs.[3]


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