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Zeb1

 

Zeb1

Zinc finger E-box binding homeobox 1

PDB rendering of ZEB1's homeodomain based on 2e19.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[1][2][3]

TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[3][4]

Contents

  • Clinical significance 1
  • References 2
  • Further reading 3
  • External links 4

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[5]

References

  1. ^ Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (Dec 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics 14 (1): 194–6.  
  2. ^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (Feb 1992). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4.  
  3. ^ a b "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1". 
  4. ^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4.  
  5. ^ Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Lab. Invest. 94 (4): 362–70.  

Further reading

  • Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.". Mol. Cell. Biol. 14 (10): 6773–88.  
  • Watanabe Y, Kawakami K, Hirayama Y, Nagano K (1994). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene.". J. Biochem. 114 (6): 849–55.  
  • Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.". Mol. Cell. Biol. 18 (1): 10–8.  
  • Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40.  
  • Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8.  
  • Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T (2001). "Tip60 is a cell-type-specific transcriptional regulator.". J. Biochem. 129 (4): 635–41.  
  • Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S (2002). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology.". J. Bone Miner. Res. 16 (12): 2192–204.  
  • Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S (2002). "Effects of HIV-1 Nef on cellular gene expression profiles.". J. Biomed. Sci. 9 (1): 82–96.  
  • Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J (2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.". J. Biol. Chem. 277 (42): 39209–16.  
  • Costantino ME, Stearman RP, Smith GE, Darling DS (2002). "Cell-specific phosphorylation of Zfhep transcription factor.". Biochem. Biophys. Res. Commun. 296 (2): 368–73.  
  • Postigo AA (2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.". EMBO J. 22 (10): 2443–52.  
  • Postigo AA, Depp JL, Taylor JJ, Kroll KL (2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.". EMBO J. 22 (10): 2453–62.  
  • Dillner NB, Sanders MM (2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades.". DNA Cell Biol. 23 (1): 25–34.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5.  
  • Shimizu S, Krafchak C, Fuse N, Epstein MP, Schteingart MT, Sugar A, Eibschitz-Tsimhoni M, Downs CA, Rozsa F, Trager EH, Reed DM, Boehnke M, Moroi SE, Richards JE (2005). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10.". Am. J. Med. Genet. A 130 (4): 372–7.  
  • Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R (2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.". Oncogene 24 (14): 2375–85.  

External links

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