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The Role of Metals in Carcinogenesis : Biochemistry and Metabolism

By Jennette, K. Wetterhahn

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Book Id: WPLBN0000093642
Format Type: PDF eBook
File Size: 1.3 MB
Reproduction Date: 2005

Title: The Role of Metals in Carcinogenesis : Biochemistry and Metabolism  
Author: Jennette, K. Wetterhahn
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Jennette, K. W. (n.d.). The Role of Metals in Carcinogenesis : Biochemistry and Metabolism. Retrieved from

Government Reference Publication

Excerpt: The biochemistry and metabolism of inorganic species involved in carcinogenesis encompasses transport of inorganic species across the cell membrane, enzymatic and chemical transformation of redox active inorganic species within the cell, coordination of inorganic species to cellular small molecules and macromolecules, and inhibition, activation or change of specificity of cellular enzymes by inorganic species. Inorganic species may mimic forms of essential elements in these arocesses. The kinetic and thermodynamic propertie5 of int)rg.anic species may be substantially different from those of essential elements and, therefore, may ultimately determine the manifestation of cellular damage, including carcinogenic and cocarcinogenic effects. For example, in order for an inorganic compound to be a mutagen it must enter the cell; however, an inorganic compound may be able to act as a cocarcinogen without penetration into the cell by interacting with the cell surface.


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