World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Toxicological Review of Methyl Ethyl Ketone

By Rieth, Susan

Click here to view

Book Id: WPLBN0000109624
Format Type: PDF eBook
File Size: 0.9 MB
Reproduction Date: 2007

Title: Toxicological Review of Methyl Ethyl Ketone  
Author: Rieth, Susan
Volume:
Language: English
Subject: Ecology, Natural resource issues, Environemtal protection
Collections: Environmental Awareness Library Collection
Historic
Publication Date:
Publisher: United States Environmental Protection Agency

Citation

APA MLA Chicago

Rieth, S. (n.d.). Toxicological Review of Methyl Ethyl Ketone. Retrieved from http://www.hawaiilibrary.net/


Description
Excerpt: The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to methyl ethyl ketone. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of methyl ethyl ketone.

Table of Contents
CONTENTS —TOXICOLOGICAL REVIEW OF METHYL ETHYL KETONE (CAS No. 78-93-3) LIST OF TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii FOREWORD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . viii AUTHORS, CONTRIBUTORS, AND REVIEWERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS . . . . . 3 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.1. ABSORPTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.1.1. Oral Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.1.2. Inhalation Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.1.3. Dermal Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.2. DISTRIBUTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3.3. METABOLISM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.4. ELIMINATION AND EXCRETION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 3.5. PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELS . . . . . 12 4. HAZARD IDENTIFICATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.1. STUDIES IN HUMANS - EPIDEMIOLOGY, CASE REPORTS, CLINICAL CONTROLS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.1.1. Oral Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.1.2. Inhalation Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.1.2.1. Acute Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.1.2.2. Case Studies of Long-term Human Exposure to MEK . . . . . . . . . . . . 19 4.1.2.3. Occupational Studies of MEK Exposure . . . . . . . . . . . . . . . . . . . . . . 20 4.2. PRECHRONIC AND CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS–ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 4.2.1. Oral Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 4.2.2. Inhalation Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 4.3. REPRODUCTIVE/DEVELOPMENTAL STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . 34 4.3.1. Studies in Humans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 4.3.2. Studies in Animals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 4.3.2.1. Oral Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 4.3.2.2. Inhalation Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 4.4. OTHER STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 4.4.1. Acute Toxicity Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 4.4.1.1. Oral Exposure . . . . . . . . . . . . . . . . .

 

Click To View

Additional Books


  • And Gulliver Returns Book II : Are We Di... (by )
  • And Gulliver Returns Book I : Touchdown (by )
  • And Gulliver Returns Book VII : Book 7 V... (by )
  • I and Thou (by )
  • The Giant Mushroom (by )
  • Annals, From the Death of the Divine Aug... (by )
  • And Gulliver Returns Book IV : A Look at... (by )
  • And Gulliver Returns Book III : A Visit ... (by )
  • New Theory of Thermal Stability in Boili... (by )
  • Circular-Engineering Extension Service (by )
  • The New Engineering (by )
  • Essays (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.