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World Health Organization Publication : Year 2005 ; Issue 9251052425: Pesticide Residues in Food ; 2004

By World Health Organization

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Book Id: WPLBN0000212371
Format Type: PDF eBook
File Size: 2.1 MB
Reproduction Date: 2005
Full Text

Title: World Health Organization Publication : Year 2005 ; Issue 9251052425: Pesticide Residues in Food ; 2004  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

Description
Medical Reference Publication

Excerpt
At its Twenty-fifth Session in 1993 (ALINORM 93/24A para. 251), the CCPR identified chlorpyrifos as a candidate for periodic review. At its Twenty-ninth Session in 1997, it scheduled periodic reviews for toxicology in 1999 and for residue chemistry in 2000. The 1999 toxicology review confirmed the ADI of 0.01 mg/kg bw and also established an ARfD of 0.1 mg/kg bw. In the 2000 residue chemistry review, information was supplied on the identity and physical properties of the active ingredient and technical material, metabolism in plants and animals, environmental fate, storage stability, animal feeding studies, field trials, GAP (national labels) and fate of residues in processing. Chlorpyrifos was scheduled for re-evaluation in 2004 for consideration of maximum residue levels in cotton, potato, rice and soya bean. No MRLs were recommended by the 2000 JMPR on these commodities because of lack of relevant GAP labels or insufficient residue data. Relevant GAP labels and additional residue data to support proposed Codex MRLs in these commodities were submitted to the Meeting for evaluation. The CCPR at its Thirty-sixth Session in 2004 agreed that JMPR would review data from India to support establishment of a maximum residue level on tea. Information was submitted by the Government of India for this purpose.

Table of Contents
CONTENTS List of participants ............................................................................................................................... v Abbreviations ...................................................................................................................................... x Use of JMPR reports and evaluations by registration authorities ........................................................ xi 1. Introduction ............................................................................................................................... 1 2. General considerations ............................................................................................................... 3 2.1 Guidance on the establishment of acute reference doses .................................................. 3 2.2 Definition of ‘overall NOAEL’ ........................................................................................ 9 2.3 Interim acute reference dose ............................................................................................. 9 2.4 Progress report on the JMPR work-sharing pilot project on trifloxystrobin .................... 10 2.5 Comparison of JMPR recommendations and interim MRL recommendations from the CCPR pilot project ......................................................................................... 13 2.6 Estimation of maximum residue levels of pesticides in or on spices on the basis of monitoring results ..................................................................................................... 19 2.7 Revisited: MRLs for fat-soluble pesticides in milk and milk products ............................ 24 2.8 Revisited: Dietary burden of animals for estimation of MRLs for animal commodities .................................................................................................................. 26 2.9 Statistical methods for estimating MRLs ......................................................................... 29 2.10 Application of the recommendations of the OECD project on minimum data requirements to the work of the JMPR. ........................................................................ 30 2.11 Alignment within one year of toxicological and residue evaluations for new and periodically reviewed compounds ................................................................................ 33 3. Dietary risk assessments for pesticide residues in foods ........................................................... 35 4. Evaluation of data for establishing values for acceptable daily intakes and acute reference doses for humans, maximum residue limits and supervised trial median residue levels ............ 39 4.1 Bentazone (T, D) ............................................................................................................. 39 4.2 Captan (T, D) .................................................................................................................. 40 4.3 Carbofuran from carbosulfan (R, D) ............................................................................... 42 4.4 Chlorpyrifos (R, D) ......................................................................................................... 44 4.5 Dimethipin (T, D) ............................................................................................................ 48 4.6 Dithiocarbamates (R) ...................................................................................................... 49 4.7 Ethoprophos (R, D) ......................................................................................................... 50 4.8 Fenitrothion (R, D) .......................................................................................................... 62 4.9 Fenpropimorph (T, D) ........................................................................................

 

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