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Plos One : Morphology and Viscoelasticity of Actin Networks Formed with the Mutually Interacting Crosslinkers ; Palladin and Alpha-actinin, Volume 7

By Kreplak, Laurent

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Book Id: WPLBN0003957153
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Morphology and Viscoelasticity of Actin Networks Formed with the Mutually Interacting Crosslinkers ; Palladin and Alpha-actinin, Volume 7  
Author: Kreplak, Laurent
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
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Publisher: Plos

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Kreplak, L. (n.d.). Plos One : Morphology and Viscoelasticity of Actin Networks Formed with the Mutually Interacting Crosslinkers ; Palladin and Alpha-actinin, Volume 7. Retrieved from http://www.hawaiilibrary.net/


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Description : Actin filaments and associated actin binding proteins play an essential role in governing the mechanical properties of eukaryotic cells. Even though cells have multiple actin binding proteins (ABPs) that exist simultaneously to maintain the structural and mechanical integrity of the cellular cytoskeleton, how these proteins work together to determine the properties of actin networks is not clearly understood. The ABP, palladin, is essential for the maintenance of cell morphology and the regulation of cell movement. Palladin coexists with a-actinin in stress fibers and focal adhesions and binds to both actin and a-actinin. To obtain insight into how mutually interacting actin crosslinking proteins modulate the properties of actin networks, we characterized the micro-structure and mechanics of actin networks crosslinked with palladin and aactinin. We first showed that palladin crosslinks actin filaments into bundled networks which are viscoelastic in nature. Our studies also showed that composite networks of a-actinin/palladin/actin behave very similar to pure palladin or pure aactinin networks. However, we found evidence that palladin and a-actinin synergistically modify network viscoelasticity. To our knowledge, this is the first quantitative characterization of the physical properties of actin networks crosslinked with two mutually interacting crosslinkers.

 

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