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Polr2e

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Polr2e

Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
Identifiers
2.7.7.6
RNA expression pattern

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.[1]

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.[2]

Interactions

POLR2E has been shown to interact with TAF15,[3] POLR2C,[4] POLR2G,[4] POLR2H,[4] POLR2A,[4] POLR2B,[4] POLR2L[4] and GTF2F2.[5]

References

Further reading

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