World Library  
Flag as Inappropriate
Email this Article

Tripartite motif family

Article Id: WHEBN0015939973
Reproduction Date:

Title: Tripartite motif family  
Author: World Heritage Encyclopedia
Language: English
Subject: Trim
Publisher: World Heritage Encyclopedia

Tripartite motif family

The tripartite motif family (TRIM) is a protein family.[1]


Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses. TRIM proteins are involved in pathogen-recognition and by regulation of transcriptional pathways in host defence.[2]


The tripartite motif is always present at the N-terminus of the TRIM proteins. The TRIM motif includes the following three domains:[1]

  • (1) a RING finger domain
  • (2) one or two B-box zinc finger domains
    • when only one B-box is present, it is always a type-2 B-box
    • when two B-boxes are present the type-1 B-Box always precedes the type-2 B-Box
  • (3) coiled coil region

The C-terminus of TRIM proteins contain either:

  • Group 1 proteins: a C-terminal domain selected from the following list:
  • Group 2 proteins: a SPRY C-terminal domain
    • e.g. TRIM21

Family members

The TRIM family is split into two groups that differ in domain structure and genomic organization:[3]

  • Group 1 members possess a variety of C-terminal domains, and are represented in both vertebrate and invertebrates
  • Group 2 is absent in invertebrates, possess a C-terminal SPRY domain[4]

Members of the family include:

  • Group 1
    • PHD-BROMO domain containing: TRIM24 (TIF1α), TRIM28 (TIF1β), TRIM33 (TIF1γ)– act as corepressors
    • 1-10: TRIM1, TRIM2, TRIM3, TRIM8, TRIM9
    • 11-20: TRIM12, TRIM13, TRIM14, TRIM16, TRIM18, TRIM19
    • 21-30: TRIM23, TRIM25, TRIM29, TRIM30
    • 31-40: TRIM32, TRIM36, TRIM37
    • 41-50: TRIM42, TRIM44, TRIM45, TRIM46, TRIM47
    • 51-60: TRIM51, TRIM53, TRIM54, TRIM55, TRIM56, TRIM57, TRIM59
    • 61-70: TRIM62, TRIM63, TRIM65, TRIM66, TRIM67, TRIM69, TRIM70
    • 71-75: TRIM71
  • Group 2
    • 1-10: TRIM4, TRIM5, TRIM6, TRIM7, TRIM10
    • 11-20: TRIM11, TRIM12, TRIM15, TRIM17, TRIM20
    • 21-30: TRIM21, TRIM22, TRIM26, TRIM27, TRIM30
    • 31-40: TRIM31, TRIM34, TRIM35, TRIM38, TRIM39, TRIM40
    • 41-50: TRIM41, TRIM43, TRIM48, TRIM49, TRIM50
    • 51-60: TRIM51, TRIM52, TRIM53, TRIM57, TRIM58, TRIM60
    • 61-70: TRIM61, TRIM64, TRIM68, TRIM69, TRIM70
    • 71-75: TRIM72, TRIM73, TRIM74, TRIM75


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.